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Board of Directors

Steven M. Altschuler, M.D.
Chairman, Spark Therapeutics; Chief Executive Officer, The Children’s Hospital of Philadelphia

Dr. Steven M. Altschuler has been chief executive officer of The Children’s Hospital of Philadelphia (CHOP) since 2000. Previously, Steve served in many leadership roles at CHOP including: division chief of Gastroenterology, physician-in-chief, inaugural holder of the Leonard and Madlyn Abramson Endowed Chair in Pediatrics and professor and chair of the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

Steve’s tenure as CEO has seen the most significant growth in the Hospital’s 159-year history. Beyond its Main Campus in University City, CHOP maintains an extensive Care Network that provides primary, specialty and urgent care, and more at over 50 locations in the Philadelphia region. The Hospital’s International Medicine program—encompassing patient care, professional education and clinical partnerships—is one of the largest in the world. A respected advocate for children’s health, Steve has spearheaded innovative multi-institution efforts to better coordinate services for complex patients, thus reducing financial burden and improving care.

CHOP’s Research Institute, number one in NIH funding among pediatric institutions, has made groundbreaking advances in gene therapy, T-cell therapy for cancer and prenatal treatment of birth defects. In forming Spark Therapeutics, Steve led the creation of the Hospital’s first for-profit enterprise in gene therapy.

Steve received his B.A. in mathematics and his M.D. from Case Western Reserve University. He completed his pediatric internship and residency at Children’s Hospital Medical Center-Boston and fellowship training in gastroenterology and nutrition at The Children’s Hospital of Philadelphia and the University of Pennsylvania School of Medicine. For 15 years, Steve was a faculty member of the department of pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Steve serves on the board of directors for Mead Johnson Nutritionals, Children’s Miracle Network Hospitals, the Free Library of Philadelphia, University HealthSystem Consortium, the Healthcare Institute and the GAVI Alliance Campaign.

Arthur Dantchik
Managing Director and Management Committee Member, Susquehanna International Group, LLP

Arthur Dantchik is a managing director and serves on the management committee of Susquehanna International Group, LLP, a global quantitative trading firm. He has general oversight responsibilities for SIG’s domestic energy and commodity trading businesses, as well as the firm’s private equity group and its international trading affiliates in Dublin and Sydney. He also manages SIG’s market maker training program, one of the most highly regarded curriculums on Wall Street. Arthur has over two decades experience managing derivatives and equities trading operations, including options market making on the Philadelphia Stock Exchange. He received a B.A. in biology from the State University of New York at Binghamton and attended Arizona State University for graduate study in psychology with an emphasis on decision making.

Lars Ekman, M.D., Ph.D.
Executive Partner, Sofinnova Ventures

Lars has more than 28 years of experience in senior executive, scientific, and clinical functions. He has served as executive partner at Sofinnova Ventures since 2008, lending his extensive expertise in the life sciences industry to the investment team in driving new companies toward success. Prior to joining Sofinnova Ventures, Lars was president of research and development at Elan. Lars is credited with advancing Elan’s drug discovery pipeline during his tenure, and under Lars’ leadership, the company received approval for four U.S. New Drug Applications, three European Marketing Approval Applications and five Investigational New Drug Applications. These efforts resulted in advancing Elan’s immunotherapeutic approach and bringing to market three neuroscience products, including Tysabri for multiple sclerosis. Prior to joining Elan, Lars was executive vice president, research and development, at Schwarz Pharma AG, and before that, held a variety of senior scientific and clinical roles at Pharmacia (now Pfizer). Lars is a board-certified surgeon with a Ph.D. in experimental biology, and an M.D., from the University of Gothenburg, Sweden.

Jeffrey D. Marrazzo, M.B.A., M.P.A.
Co-Founder, President and Chief Executive Officer, Spark Therapeutics

Jeffrey Marrazzo is co-founder, president and chief executive officer of Spark and serves on the board of directors. He is an experienced entrepreneur dedicated to curing disease through genomic medicine. Jeff was part of the founding management of Generation Health, a pharmacogenomics medicines company that was acquired by CVS Caremark in 2009, and a senior member of the business development and finance teams at Tengion, a venture-backed regenerative medicine company that went public in 2010. Most recently, Jeff launched the U.S. division of Molecular Health, Inc., securing capital and recruiting a management team for this emerging leader in personalized cancer therapy. Throughout his career, he has helped raise or place more than $150 million in venture capital and has led or co-led the formation of novel strategic partnerships with the FDA, Quest Diagnostics, GE Healthcare and SAP. Previously, he served as healthcare advisor to former Pennsylvania Governor Edward G. Rendell and as an IBM management consultant to global pharmaceutical companies. He has also advised investment firms such as Goldman Sachs, Safeguard Scientifics and BioAdvance. Jeff holds a dual M.B.A./M.P.A. from The Wharton School and Harvard University, a program which he founded and a B.S.E. and B.A. in systems science and engineering and economics from the University of Pennsylvania.

Anand Mehra, M.D.
General Partner, Sofinnova Ventures

Anand joined Sofinnova Ventures in 2007 and is focused on working with entrepreneurs to build drug development companies that have the power to improve the lives of patients. He has led the firm’s investments in Vicept Therapeutics (Acquired: Allergan), Aerie Pharmaceuticals (NASDAQ: AERI), Aclaris, and Prothena (NASDAQ: PRTA), and he played a key role in the firm’s investments in SarCode (Acquired: Shire), Preglem (Acquired: Gedeon Richter), and Amarin (NASDAQ: AMRN). He is currently a director of Aerie, Marinus Pharmaceuticals, and Spark Therapeutics, and was on the board of Nextwave Pharmaceuticals until their acquisition by Pfizer.

Prior to joining Sofinnova, Anand worked in JP Morgan’s private equity and venture capital group, where he was heavily involved in new investments, management of their public portfolio, and the firm’s spin-out from the bank. Before joining the venture community, Anand was a consultant in McKinsey & Company’s pharmaceutical practice, advising pharma and biotech on key strategic issues, and an NIH-funded Fellow focused on reperfusion injury in stroke. Anand received his M.D. from Columbia University’s College of Physicians and Surgeons and graduated Phi Beta Kappa from the University of Virginia where he was an Echols Scholar.

Vin Milano
Former president and CEO, ViroPharma

Vin most recently served as president, chief executive officer and chairman of the board of directors of ViroPharma Incorporated, which was acquired by Shire Pharmaceuticals in January 2014, and was focused on bringing innovative therapies to market for serious, unmet medical needs. ViroPharma’s lead product was Cinryze, approved and commercially available in the United States for the prevention of hereditary angioedema attacks and in Europe for both the treatment and prevention of hereditary angioedema attacks, a rare disease. Vin joined the company in 1996 and served as vice president, chief financial officer, and treasurer from 1997 to 2006. He was instrumental in building the company, including leading efforts in raising nearly $900 million in capital, as well as the acquisitions of Lev Pharmaceuticals, and the drug Vancocin from Eli Lilly. Vin played critical roles in all business development and investor relations activities for ViroPharma, as well as contributed significantly to establishing the strategic focus of the company. Prior to joining ViroPharma, Vin served as senior manager at KPMG LLP, independent certified public accountants. He received his Bachelor of Science degree in accounting from Rider College.

Elliott Sigal, M.D., Ph.D.
Former Director, Executive Vice President and Chief Scientific Officer, Bristol-Myers Squibb

Dr. Elliott Sigal has over 25 years of combined experience in medicine, research and executive management. Most recently, he served as director, executive vice president and chief scientific officer and president of R&D at Bristol-Myers Squibb from 2004 until 2013. Elliott was a principal architect of the company’s successful Biopharma Transformation Strategy which is fully dedicated to innovative therapies for unmet medical needs, and was instrumental in increasing R&D productivity, developing the company’s strategy in biologics and acquiring external innovation in its String of Pearls initiative. Under his leadership, fourteen new medicines were brought to market. Elliott previously held positions of increasing responsibility in drug discovery at the pharmaceutical company Syntex and also was vice president of R&D and chief executive officer for the genomics firm Mercator Genetics, where he provided the research leadership that resulted in the discovery of the gene for hemochromatosis, a common disorder that leads to iron overload, diabetes and liver disease.

Elliott received his M.D. from the University of Chicago and trained in internal medicine and pulmonary medicine at the University of California, San Francisco (UCSF). He received his research training at the Cardiovascular Research Institute at UCSF and served on the faculty of the UCSF Department of Medicine. He received his B.S., M.S. and Ph.D. in industrial engineering from Purdue University. Elliott currently serves as a member of the board of directors for the Mead Johnson Nutrition Company, the Melanoma Research Alliance and the University of California San Francisco Nina Ireland Program for Lung Health.

Rogério Vivaldi, M.D., M.B.A.
Chief Executive Officer and President, Minerva Neurosciences, Inc.

Dr. Rogério Vivaldi is chief executive officer and president of Minerva Neurosciences, Inc., a clinical-stage biopharmaceutical company focused on the development and commercialization of a portfolio of product candidates to treat patients suffering from neuropsychiatric diseases. Over the past 20 years Rogério has been involved in commercializing around 20 pharmaceutical products addressing a wide range of unmet medical needs, mainly within the Rare Diseases therapeutic area. He most recently served as senior vice president and head of the Rare Diseases business unit at Genzyme, a Sanofi company. Prior to that he led the establishment of Genzyme’s business operations in Brazil and served as president of Genzyme Latin America. During his 17 year tenure at Genzyme, he spearheaded the company’s patient-centric approach to product development and marketing and he has extensive experience in building relationships with government and regulatory agencies and patient advocacy organizations.

For 18 years Rogério also owned a private medical practice specializing in diabetes and endocrinology care. He received his medical degree from Rio de Janeiro University (UNIRIO) and completed his residency in metabolism and endocrinology at Rio de Janeiro State University (UERJ) and his fellowship at Mount Sinai Hospital Center in New York, Department of Genetics with an emphasis on Gaucher’s disease. He completed his M.B.A. at Coppead, Rio de Janeiro Federal University (UFRJ). Rogério was the first Brazilian medical doctor to treat a patient in Brazil with enzyme replacement therapy for Gaucher’s disease in 1992.